Particle swarm optimization-based stator resistance observer for speed sensorless induction motor drive

This paper presents a different technique for the online stator resistance estimation using a particle swarm optimization (PSO) based algorithm for rotor flux oriented control schemes of induction motor drives without a rotor speed sensor. First, a conventional proportional-integral controller-based stator resistance estimation technique is used for a speed sensorless control scheme with two different model reference adaptive system (MRAS) concepts. Finally, a novel method for the stator resistance estimation based on the PSO algorithm is presented for the two MRAS-type observers. Simulation results in the Matlab/Simulink environment show good adaptability of the proposed estimation model while the stator resistance is varied to 200% of the nominal value. The results also confirm more accurate stator resistance and rotor speed estimation in comparison with the conventional technique

Additional file 1 of A Czech version of the Overall Anxiety Severity and Impairment Scale (OASIS): standardization and psychometric properties

Additional file 1

Folding of guanine quadruplex molecules \u2013 funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies

Background Guanine quadruplexes (GQs) play vital roles in many cellular processes and are of much interest as drug targets. In contrast to the availability of many structural studies, there is still limited knowledge on GQ folding. Scope of review We review recent molecular dynamics (MD) simulation studies of the folding of GQs, with an emphasis paid to the human telomeric DNA GQ. We explain the basic principles and limitations of all types of MD methods used to study unfolding and folding in a way accessible to non-specialists. We discuss the potential role of G-hairpin, G-triplex and alternative GQ intermediates in the folding process. We argue that, in general, folding of GQs is fundamentally different from funneled folding of small fast-folding proteins, and can be best described by a kinetic partitioning (KP) mechanism. KP is a competition between at least two (but often many) well-separated and structurally different conformational ensembles. Major conclusions The KP mechanism is the only plausible way to explain experiments reporting long time-scales of GQ folding and the existence of long-lived sub-states. A significant part of the natural partitioning of the free energy landscape of GQs comes from the ability of the GQ-forming sequences to populate a large number of anti-syn patterns in their G-tracts. The extreme complexity of the KP of GQs typically prevents an appropriate description of the folding landscape using just a few order parameters or collective variables. General significance We reconcile available computational and experimental studies of GQ folding and formulate basic principles characterizing GQ folding landscapes